2020-05-16/17 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: Only 1 case in NM state prisons. NM case count. NM travel warning. NM web-based recovery reporting system. NM Mask Madness Tournament. Face covering in ABQ. NM graduate medical program funding. ABQ Memorial Day cancellation. NM affordable housing funding. Taos farmers market drive through opening. US correctional facility cases. Social distancing works. Dogs sniffing out COVID-19. Germany\u27s soccer league to restart. Mask effectiveness. Mask comfort w/cardboard cutout. Ammonium cleaning ineffective. CDC contact tracing guidance. Spanish immunity. CDC epidemic intelligence fellowship. Speaking transmits virus. Decontaminating workers. CDC advisory for children. Addressing ER fears. Indoor presymptomatic virus transfer. Virus transmission of currency. Safety advice for reopening. Lessons learned from universities. Dutch safe sex guidelines for singles. Recommendations are given on invasive management of acute coronary syndrome, onco-gynecologic surgery, endoscopy, hemodialysis, on resuming orthopedic surgery, clozapine monitoring, starting ADHD medications, orthodontics, and scaling up virtual services. At-home sample collection kit. Hydroxychloroquine no benefit. Tocilizumab reduces mortality rate. Calcium channel blockers beneficial. COVID-19 opinion/review vs. primary research. Disease severity and biomarkers. Concomitant liver injury. Gastrointestinal and liver involvement. Diabetes mortality. High incidence venous thrombosis. Monitoring global emotions with twitter

2020-06-15/16 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case updates. Tribal outreach campaign. Santa Fe firefighters support first responders. US Highlights: COVID-19 hospitalizations rise in Texas. US retail sales up in May. Projected COVID-19 deaths in US. International Highlights: COVID-19 prevention and control in Africa. COVID-19 response and challenge in Africa. Epidemiology Highlights: Herd immunity in Europe. Social distance measures effects. Modeling infections in India. Fecal analysis. Wastewater-based Epidemiology Consortium. Healthcare Policy Recommendations: Public health approach to lockdown debate. All of Us Program adds new COVID-19 initiatives. Practice Guidelines: Guidelines are reviewed on urology care. IBD endoscopy. Convalescent plasma use. Testing: Patient predictors of risk for positive COVID-19 test are reported and an online risk calculator is now available. Drugs, Vaccines, Therapies, Clinical Trials: Steroid dexamethasone reduces 28-day mortality by 1/3. Research links ‘inflamm-aging’ and cytokine storm in elderly. Cancer drug may reduce severe COVID-19. 48 new trials registered. Other Science: Postpone surgery. Proteins predict outcomes. Neurologic manifestations. Thromboembolic risk. Zoonotic transmission. Liver failure. Cardiac complications

2020-06-24/25 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: Governor update. NM schools reopening. Parents split on allowing kids play sports. Santa Fe streets closure. Paid leave for ABQ businesses. 207 cases and 5 deaths. International Highlights: 9% HCW positive in Italy. Australian lessons. Economics, Workforce, Supply Chain, PPE: Plan for return to normalcy. Mask cleaning. Epidemiology Highlights: US years of life lost high. Fever and cough most prevalent symptoms. Hypertension and diabetes most prevalent comorbidities. Hypertension, diabetes and respiratory disease most prevalent in fatal cases. Practice Guidelines: Brazilian guidelines on thromboembolic complications in COVID-19. Novel design of door handle to touch with a forearm. Drugs, Vaccines, Therapies, Clinical Trials: Potential dexamethasone shortage. Arbidol potentially effective. Pixatimod promising. In-silico repurposing. 51 new COVID-19 trials. Other Science: Transmission prior to symptoms. Solar inactivation of coronaviruses. Risk factors for severity. Laboratory tests associated with outcomes

2020-06-19/20/21 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: Dr. Scrase on-line briefing. NM cases. Campgrounds closed through July 4th. Otero prison reports. Navajo nation’s first police dies. Santa Fe cancels 4th July fireworks. Face coverings donated. NM infection rate drops. US Highlights: AZ Governor issues Exec Order. Economics, Workforce, Supply Chain, PPE: Epidemiology Highlights: Reopening hospitals metric. Comparison of mask effectiveness. Private practices suffer. Healthcare Policy Recommendations: Maternal mortality. Practice Guidelines: Recommendations on hepatobiliary surgery and neonate management. Drugs, Vaccines, Therapies, Clinical Trials: Animal studies generate new vaccine candidates and vaccine platform. 16 new clinical trials registered. Other Science: Respiratory secretions detected by trained dogs. MRI findings show brain lesions in non-survivors. Healthy blood vessels may protect children. Meta-analysis on pneumonia severity. Smoking and COVID-19 severity meta-analysis

2020-06-29/30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM cases update. ABQ nursing home hit hard. UNM student family housing closure. White Sands National Park reopening. 52% of federal COVID-19 relief money for tribal communities. Bill signed to help NM taxpayers. US Highlights: Polarization of political elite response on Twitter. International Highlights: China’s military to use Ad5-nCoV vaccine in trials. Economics, Workforce, Supply Chain, PPE: Decontaminate N95 respirators using a microwave. Epidemiology Highlights: Mask-wearing prevents transmission. Face-masks associated with Italy’s declining epidemic. Healthcare Policy Recommendations: Social distancing reassessed? Lessons learned from previous pandemics. Digital tools against COVID-19. Investigating cultural and psychological factors to reduce spread. Practice Guidelines: Preserving couple relationships during COVID-19. Testing: No difference in viral load between symptomatic and asymptomatic individuals. A new fast point-of-care virus detection test. Few patient serum samples have virus RNA (at low viral load) and these are not associated with infectious disease. Symptoms and temperature reports are informative to screen health care workers. Drugs, Vaccines, Therapies, Clinical Trials: 37 new trials registered June 29-30. Other Science: Multisystem pediatric inflammatory syndrome. Hazardous postoperative outcomes. Childhood immunization in Africa. Citizen science and protein folding

2020-06-22/23 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: Balloon Fiesta postponed. Robot to sanitize ABQ International Sunport. NMSU plan for fall 2020. NM public schools reopening plan. Fewer hospitalizations for COVID-19. NM case update. US Highlights: Visa restrictions. International Highlights: Second wave in South Korea. Epidemiology: Lockdown can suppress COVID-19. Case fatality rate associated with incidence. Predictors of ICU care and ventilators. Anxiety and depression from COVID-19. Asymptomatic patients as source of infection. Heterogeneous populations affect herd immunity. Healthcare Policy Recommendations: New FDA guidance on clinical trials conduct. Practice Guidelines: The guidelines are provided on COVID-19 diagnostics (Infectious Diseases Society of America), respiratory support for COVID-19 patients and optimizing mental care delivery during COVID-19 pandemic. Drugs, Vaccines, Therapies, Clinical Trials: Antithrombotic therapy systematic review. Drug repurposing. 58 new trials. Other Science: Safety of antihypertensives (ACEs and ARBs). Low testosterone linked to escalation of care. Neurological findings and hypercoagulability

2020-05-22 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: 12 positive cases at NMSU. Short-term rentals restrictions. Dine-in reopening. US Highlights: Models to forecast COVID-19 deaths. Places of worship reopening. Contact tracing at University of Alabama. International Highlights: More deaths among poor. Mortality data in Italy. High death toll in Brazil. Global vaccines fall behind. Italy cases drop. Vaccines to go through India. Epidemiology Highlights: Children not pandemic drivers. Healthcare Policy Recommendations: Burnout of HCWs. NYC surgeons’ response. Foggy glasses tips. Practice Guidelines: Recommendations are provided on surgical strategies during COVID-19, management of hypertension, anesthesia practice, avoiding drug-induced cardiovascular impairments, arrhythmia management, elective surgery reboot, nutritional management, stroke care, neurointerventional surgery, blood management. Testing: Unregulated tests identified. Interpreting test results. Drugs, Vaccines, Therapies, Clinical Trials: Vaccine trials results. Vaccine moves to trials. Monoclonal antibody identified. Hydroxychloroquine no benefit. Adjuvant corticosteroid therapy. Old drugs may benefit. Vaccines inducing antibodies. Other Science: Mortality and CKD/liver disease. Transmission in pregnancy. Pathophysiology insights. Readmission characteristics. Sodium and severity. Simulated sunlight disinfects

2020-05-04 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM convalescent plasma call. NM case counts. Gallup lockdown continues. Tribal federal relief delay. Childcare demand drops. Polling open for primaries. Non-US world funds R&D. South Korea eases more. Soft quarantine inefficiency. Chinese interventions. Transmission window. December French case. CDC on law enforcement, essential errands. NEJM on telemedicine. Practice guidelines for: ECMO, pneumonia, nuclear medicine SOP. FDA antibody test restrictions. Africa testing differences. PCR assay sensitivity. Wuhan antibody tracking. Hydroxychloroquine toxicity. Remdesivir mechanism. Tocilzumab study inconclusive. SARs-CoV-2 structure. 28 new trials. Immunology and exercise. Synthetic SARS-CoV-2. IgM and IgG responses. Bacterial and fungal coinfection. Youth mental health challenges

2020-05-05 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM cases. Navajo cases. NM remdesivir inaccessible. Infected prison staff. No early prison releases. Unemployment beats working. NM $97M food benefits. UNM$50M revenue loss. Meat packer testing. Fall school reopening planning. Gym/salon reopening plans. 91k absentee ballots. Santa Fe closes polling stations. NM oil/gas pollution oversight. Prisons vulnerable. WH rejects FEMA report. Schools plan reopening. Italian mafia concerns. UK overtakes Italy. Symptom tracker early warning. Ethanol for FFP2 masks. Counterfeit masks. Mask skin damage. Mutant coronavirus more contagious. Hospital contamination zones. Disease prevalence estimation. Successful control measures. Average contagious period. Genetic epidemiology. Managing healthcare resources. Exercise and fitness. Italian disease management Q&A. Practice guidelines on: bronchoscopy, sarcoidosis management, glycemic control, key laboratory tests, ACE/ARB Tx, neurosurgery, cardiac surgery. WHO: test old pneumonia samples. SW NM free testing. Diagnostic assays compared. Corticosteroid benefits. Beekeepers COVID-free? European vaccine US trials. Cytokine storm interventions. Lopinavir-ritonavir second chance. Melatonin potential Tx. 48 clinical trials. Placental infection. Cytokine severity markers. Male lungs worse. Sleep problems. IBD physician survey. Researcher career impact

2020-06-17/18 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case count. UNM housing plan for fall 2020. Navajo Nation health and social inequities. US Highlights: Banning airline passengers. Economics, Workforce, Supply Chain, PPE: COVID-19 Exit Strategy. Effect of extended use respirators and PPE. Epidemiology Highlights: Model predicts effects of strategies on US epidemic. Index for assessing risk of contagion. Practice Guidelines: Institutional antithrombotic protocols in US and France are reviewed. Shortcomings of restricted hospital visitation are discussed. Testing: Current testing strategies and assays. Reducing transmission in incarcerated populations. Drugs, Vaccines, Therapies, Clinical Trials: More detail on dexamethasone trial. Methylprednisolone improved outcomes. Outcomes on ACEI/ARB. 34 new trials. Other Science: Nearly 20% of world’s population is at risk for severe disease. High-flow nasal cannula for acute respiratory failure. Genome-wide association study of patients with severe disease. Frail geriatric COVID-19 patients have a higher risk of delirium. Asymptomatic infection is associated with a longer virus shedding and a weaker immune response